During a monologue introducing his new Netflix talk show on Wednesday night, the comic John Mulaney said the streamer had given him an hour to introduce his fans to the baby boomer culture that has made him “the unsettled weirdo” he is today.

He stayed true to his word. The premiere episode of “Everybody’s Live With John Mulaney” included jokes about Al Jarreau, an eccentric tribute to “Death of a Salesman” and an appearance by Joan Baez, who gossiped about civil rights leaders.

Scheduled for a 12-week run, “Everybody’s Live” is a follow-up to Mulaney’s first stab at the format, “Everybody’s in L.A.” That show, also live, aired last May as an eccentric but enjoyable exercise in corporate synergy: It coincided with the Netflix Is a Joke Fest, and it included plenty of Mulaney’s fellow comedy stars as guests, along with call-in segments and offbeat bits about Los Angeles concerns like coyotes and earthquakes. “Everybody’s Live” recreated that show for a slightly wider audience. It’s not quite as Los Angeles-centric; it’s still just as weird.

The show is Netflix’s latest foray into live programming. The streamer has been experimenting with live events like a Chris Rock standup special in 2023 and the Jake Paul-Mike Tyson boxing match and Screen Actors Guild Awards this year.

So what can viewers expect if they tune in to see Mulaney on Wednesday nights? Here are some clues from the premiere.

So was ‘Everybody’s Live’ basically ‘Everybody’s in L.A. 2’?

Yes. Mulaney explained in the monologue that they changed the title because Netflix did a focus group and “it turns out people around the country don’t like L.A.” Mulaney suggested testing the name again after the wildfires earlier this year to see if opinions had changed, he said. They hadn’t.

Despite the slightly different title, “Everybody’s Live” follows the same format as “Everybody’s in L.A.” Mulaney assembles a group of guests — a seemingly random assortment of celebrities and subject experts — to discuss a topic and take calls from viewers. Instead of commercial breaks, there are short interstitial man-on-the-street interviews during the livestream, though Netflix will insert commercials later for on-demand viewers who subscribe to one of the service’s ad tiers.

Episodes of “Everybody’s in L.A.” were centered on things related to the city, like “coyotes” and “helicopters.” Mulaney has gone broader for the new show. This week’s episode was nominally focused on “lending people money.” The guests — Michael Keaton; Fred Armisen; Baez; and Jessica Roy, a personal finance columnist for The San Francisco Chronicle — discussed their own experiences with lending and borrowing and weighed in on live callers’ horror stories about giving money to family members and delinquent roommates.

One person claimed he had taken $20,000 from his brother to go to law school but used the money instead to buy a car, which he then crashed. Most of the calls were more uncomfortable than funny.

Was Richard Kind there?

He sure was! Thank goodness. Kind, the hard-working character actor, is back as Mulaney’s Ed McMahon, his boisterous laugh echoing throughout the studio. Mulaney, who recently shared a Broadway stage with Kind in “All In,” said on Wednesday that he once saw his sidekick steal a six pack of tube socks from a costume closet. This tracks: Kind routinely takes clothing from his jobs.

Were there any other sidekicks?

Does a delivery robot named Saymo count as a sidekick? Frankly, there could have been more Saymo gags. Also, Tracy Morgan made an appearance as a character called “King Latifah,” though it is unclear whether he will be back for future installments.

Did Mulaney get personal?

Since Mulaney’s much chronicled struggle with addiction, his standup comedy has been generally more revealing about his personal life. Wednesday’s monologue centered on his wife, Olivia Munn, who has undergone multiple procedures to treat breast cancer. While this doesn’t sound like classic comedy show material, Mulaney told amusing stories about Munn’s “cancer brain.” “It’s a sweet, wonderful dumbness that happens after all that challenging treatment,” he said and then shared two loving anecdotes about Munn saying or doing something jarringly profane.

How were the guests?

Mulaney’s format can lead to awkwardness among the panelists if the conversation doesn’t flow freely. At first, that seemed to be the case with Keaton telling a meandering story about going to Benihana. Baez’s anecdote about the Rev. Dr. Martin Luther King Jr. telling dirty jokes was much more entertaining, though she wouldn’t repeat any of them.

Were there any political statements?

True to form, Baez, known for her activism, had something to say. After confirming with Mulaney that she could say whatever she wanted on the live show, she gave a disclaimer of sorts. “We’re all here to be silly and have fun,” she said. “As long as we recognize the fact that our democracy is going up in flames, and we’re being run by a bunch of really incompetent billionaires.” She later told a story about crashing a Tesla.

Was there an inexplicable but hilarious sketch about ‘Death of a Salesman’ featuring Christopher Lloyd?

Yes! In a prerecorded bit, Mulaney assembled a focus group of actors who have played Willy Loman in various productions of “Salesman,” the Arthur Miller drama. They included known performers like Anthony LaPaglia, who did the play in Melbourne, Australia, and Christopher Lloyd, the man perhaps best known as Doc Brown from “Back to the Future,” who did the play at the Weston Playhouse in Vermont in 2010. They also included other professional actors and student performers.

Mulaney asked them to react in character to various topics and images — child obesity, screen time, “Mortal Kombat” — before a grand finale in which all the actors recited the “there were promises made” monologue in unison. Was it all a commentary on one of the most enduring works of American art and its continued relevance? Sure, maybe. It was also just Grade-A absurdist humor.

Did Baez and Kind dance to the hip-hop group Cypress Hill?

Indeed. The camera caught Baez and Kind grooving to the group’s “Hits From the Bong.” Even better: They have moves.